Cynata Therapeutics Limited (ASX:CYP) Treats First Patient in Kidney Transplant Trial
Cynata Therapeutics Limited (ASX: CYP) has announced the successful treatment of the first patient with CYP-001 in a Phase 1/2 clinical trial for kidney transplantation. The trial, managed by Leiden University Medical Centre (LUMC), aims to evaluate the safety and efficacy of CYP-001, a product derived from Cynata’s proprietary Cymerus™ technology.
Clinical Trial Overview
The primary aim of the trial is to assess whether CYP-001 can enable lower dosages of tacrolimus, a common immunosuppressant drug used in organ transplants. Reducing tacrolimus dosage could mitigate the associated toxicity, which includes serious health risks such as cancer and kidney damage.
Trial Design and Objectives
Up to 16 patients will be recruited for the trial, which involves administering one or two infusions of CYP-001 alongside standard treatment. Following a favourable review of initial safety results, a subsequent cohort may receive tacrolimus dose reductions.
Expert Insights
Dr. Siebe Spijker from LUMC expressed optimism, highlighting the unique capability of mesenchymal stem cells (MSCs) to modulate the immune response, potentially reducing the need for immunosuppressants. He noted the limitations of traditional bone marrow-derived MSCs compared to Cynata’s iPSC-based platform.
Executive Comments
Dr Kilian Kelly, Cynata’s CEO and Managing Director, stated, “This trial will help build the growing body of data on the use of Cymerus™ iPSC-derived MSCs in a wide range of clinical indications.” He emphasised the importance of this research in expanding treatment possibilities for kidney transplant recipients.
Motley Fool contributor Abbie Stokes has no position in any of the stocks mentioned. The Motley Fool Australia's parent company Motley Fool Holdings Inc. has no position in any of the stocks mentioned. The Motley Fool Australia has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.
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